CDKN2A (phospho S7) Peptide
产品名称： CDKN2A (phospho S7) Peptide
英文名称： CDKN2A (phospho S7) Peptide
产品编号： P1367
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of CDKN2A.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S7 of human CDKN2A.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- G1 arrest by p16INK4A uncouples growth from cell cycle progression in leukemia cells with deregulated cyclin E and c-Myc expression.
Ausserlechner MJ, Obexer P, Geley S, Kofler R.Leukemia. 2005 Jun;19(6):1051-7.
- 2.
- Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders.
Kawamata N, Inagaki N, Mizumura S, Sugimoto KJ, Sakajiri S, Ohyanagi-Hara M, Oshimi K.Eur J Haematol. 2005 May;74(5):424-9.
- 3.
- p16INK4A and p14ARF expression pattern by immunohistochemistry in human papillomavirus-related cervical neoplasia.
Wang JL, Zheng BY, Li XD, Nokelainen K, Angstrom T, Lindstrom MS, Wallin KL.Mod Pathol. 2005 May;18(5):629-37.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of CDKN2A (phospho S7) polyclonal antibody (Cat # PAB4912) in A2058 cell lysate (35 ug/lane). Phospho-CDKN2A (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with CDKN2A (phospho S7) polyclonal antibody (Cat # PAB4912) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 1029
- Protein Accession#:
- NP_000068;P42771
- Gene Name:
- CDKN2A
- Gene Alias:
- ARF,CDK4I,CDKN2,CMM2,INK4,INK4a,MLM,MTS1,TP16,p14,p14ARF,p16,p16INK4,p16INK4a,p19
- Gene Description:
- cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq
- Other Designations:
- CDK4 inhibitor p16-INK4,OTTHUMP00000021147,OTTHUMP00000021148,cell cycle negative regulator beta,cyclin-dependent kinase inhibitor 2A,cyclin-dependent kinase inhibitor p16,multiple tumor suppressor 1
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